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< Vol. 15 Issue 1 | Jan-Feb 2014 | pp. 1 - 72

Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis

Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis

J Vasc Access 2014; 15(1): 25 - 28

Article Type: ORIGINAL ARTICLE

DOI:10.5301/jva.5000151

Authors

Prabir Roy-Chaudhury, Rao Khan, Begoña Campos, Yang Wang, Michelle Kurian, Timmy Lee, Lois Arend, Rino Munda

Abstract

Purpose: Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies. 
Methods: In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis. 
Results: Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d. 
Conclusion: We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.

Article History

  • • Accepted on 25/02/2013
  • • Available online on 03/09/2013
  • • Published in print on 11/03/2014

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Authors

  • Roy-Chaudhury, Prabir [PubMed] [Google Scholar]
    Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA and Cincinnati VA Medical Center, Cincinnati, OH - USA
  • Khan, Rao [PubMed] [Google Scholar]
    Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA
  • Campos, Begoña [PubMed] [Google Scholar]
    Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA
  • Wang, Yang [PubMed] [Google Scholar]
    Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA
  • Kurian, Michelle [PubMed] [Google Scholar]
    Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA
  • Lee, Timmy [PubMed] [Google Scholar]
    Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA and Cincinnati VA Medical Center, Cincinnati, OH - USA
  • Arend, Lois [PubMed] [Google Scholar]
    Department of Pathology, University of Cincinnati, Cincinnati, OH - USA
  • Munda, Rino [PubMed] [Google Scholar]
    Division of Transplant Surgery, University of Cincinnati, Cincinnati, OH - USA

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