External beam radiation therapy for PTFE dialysis grafts: a pilot study
External beam radiation therapy for PTFE dialysis grafts: a pilot study
J Vasc Access 2012; 13(3): 329 - 331
DOI:10.5301/jva.5000052
Authors
Prabir Roy-Chaudhury, Heather J. Duncan, Darryl Zuckerman, Rashid Faiyaz, Rino Munda, Shashi Kant, Burnett Kelly, Ashwatha Narayana
Abstract
Purpose: The aim of this study was to identify the effects of external beam radiation on PTFE dialysis graft dysfunction. Methods: Seven patients who underwent PTFE dialysis graft angioplasty were randomized to receive either two 8 Gy doses of external beam radiation or no radiation. The primary endpoint was time to graft thrombosis with a secondary endpoint of time to first intervention. Results: There was no statistically significant difference between the two groups in either of the endpoints, although grafts in the radiation group had a shorter time to thrombosis or intervention. Conclusions: Our results demonstrate technical feasibility for use of external beam radiation in the setting of dialysis vascular access graft dysfunction. Larger randomized studies are required to identify whether there is a clinical benefit from this intervention.
Article History
- • Accepted on 04/12/2011
- • Available online on 23/01/2012
- • Published in print on 28/09/2012
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Authors
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Roy-Chaudhury, Prabir [PubMed] [Google Scholar]
Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA
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Duncan, Heather J. [PubMed] [Google Scholar]
Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA
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Zuckerman, Darryl [PubMed] [Google Scholar]
Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA
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Faiyaz, Rashid [PubMed] [Google Scholar]
Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA
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Munda, Rino [PubMed] [Google Scholar]
Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA
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Kant, Shashi [PubMed] [Google Scholar]
Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA
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Kelly, Burnett [PubMed] [Google Scholar]
Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA
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Narayana, Ashwatha [PubMed] [Google Scholar]
Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA